DBC1 anticorps

N° du produit ABIN6241147

Détail du produit anti-DBC1 anticorps

Antigène: DBC1 (BRINP1) (Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DBC1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Immunogène: Recombinant Protein

Information d'application

Indications d'application: IP: 1:500. WB: 1:500. ICC: 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C,-20 °C

Détails sur DBC1

Antigène: DBC1 (BRINP1) (Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1))

Autre désignation: DBC1 (BRINP1 Produits)

Synonymes: anticorps Dbc1, anticorps Dbccr1, anticorps BRINP, anticorps Fam5a, anticorps BMP/retinoic acid inducible neural specific 1, anticorps bone morphogenic protein/retinoic acid inducible neural specific 1, anticorps Brinp1, anticorps BRINP1

Sujet: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.

UniProt: Q8N163