JMJD6 anticorps (N-Term)

N° du produit ABIN6241759

Détail du produit anti-JMJD6 anticorps

Antigène: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Épitope: N-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JMJD6 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Immunogène: Recombinant Protein

Information d'application

Indications d'application: WB: 1:1000. ICC: 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C,-20 °C

Détails sur JMJD6

Antigène: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Autre désignation: JMJD6 (JMJD6 Produits)

Sujet: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

UniProt: Q6NYC1