KAP1 anticorps
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- Antigène Voir toutes KAP1 (TRIM28) Anticorps
- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp KAP1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- Immunogène
- Recombinant Protein
- Top Product
- Discover our top product TRIM28 Anticorps primaire
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- Indications d'application
- IP: 1:500. WB: 1:1000. IHC: 1:100. ICC: 1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Stock
- 4 °C,-20 °C
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- Antigène
- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
- Autre désignation
- KAP1 / TIF1 beta (TRIM28 Produits)
- Sujet
- Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation, the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
- UniProt
- Q13263
- Pathways
- Signalisation Hedgehog, Positive Regulation of Response to DNA Damage Stimulus
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