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CHD5 anticorps (AA 64-98)

CHD5 Reactivité: Humain WB Hôte: Lapin Polyclonal RB54755 unconjugated
N° du produit ABIN6242241
  • Antigène Voir toutes CHD5 Anticorps
    CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
    Épitope
    • 5
    • 3
    • 3
    • 1
    AA 64-98
    Reactivité
    • 19
    • 3
    • 1
    Humain
    Hôte
    • 17
    • 1
    • 1
    Lapin
    Clonalité
    • 18
    • 1
    Polyclonal
    Conjugué
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CHD5 est non-conjugé
    Application
    • 7
    • 6
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This CHD5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 64-98 amino acids from human CHD5.
    Clone
    RB54755
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CHD5 Anticorps primaire
  • Indications d'application
    WB: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
    Autre désignation
    CHD5 (CHD5 Produits)
    Synonymes
    anticorps CHD-5, anticorps 4930532L22Rik, anticorps AW060752, anticorps B230399N07Rik, anticorps CHD5, anticorps chromodomain helicase DNA binding protein 5, anticorps potassium voltage-gated channel subfamily A regulatory beta subunit 2, anticorps CHD5, anticorps Chd5, anticorps chd5, anticorps KCNAB2
    Sujet
    Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
    Poids moléculaire
    223050
    UniProt
    Q8TDI0
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