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ECT2 anticorps (AA 200-460)

ECT2 Reactivité: Humain WB Hôte: Souris Monoclonal 1691CT516-3-3 unconjugated
N° du produit ABIN6242298
  • Antigène Voir toutes ECT2 Anticorps
    ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))
    Épitope
    • 15
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 200-460
    Reactivité
    • 61
    • 12
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 57
    • 3
    • 1
    Souris
    Clonalité
    • 58
    • 3
    Monoclonal
    Conjugué
    • 22
    • 8
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ECT2 est non-conjugé
    Application
    • 46
    • 24
    • 19
    • 14
    • 14
    • 8
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogène
    This ECT2 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 200-460 amino acids from human ECT2.
    Clone
    1691CT516-3-3
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product ECT2 Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))
    Autre désignation
    ECT2 (ECT2 Produits)
    Synonymes
    anticorps ECT2, anticorps arhgef31, anticorps xect2, anticorps AI528536, anticorps mKIAA4037, anticorps ARHGEF31, anticorps ect2, anticorps epithelial cell transforming 2, anticorps ect2 oncogene, anticorps epithelial cell transforming 2 S homeolog, anticorps ECT2, anticorps ect2, anticorps Ect2, anticorps ect2.S
    Sujet
    Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly, regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity, participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)- induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
    Poids moléculaire
    103505
    UniProt
    Q9H8V3
    Pathways
    Neurotrophin Signaling Pathway, Cell-Cell Junction Organization
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