MELK anticorps (AA 381-415)

N° du produit ABIN6242438

Détail du produit anti-MELK anticorps

Antigène: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Épitope: AA 381-415

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MELK est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Melk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 381-415 amino acids from the Central region of Mouse Melk.

Clone: RB51207

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur MELK

Antigène: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Autre désignation: Melk (MELK Produits)

Synonymes: anticorps MELK, anticorps xmelk, anticorps Melk, anticorps HPK38, anticorps AI327312, anticorps MPK38, anticorps mKIAA0175, anticorps fb71b01, anticorps fe01f04, anticorps wu:fb71b01, anticorps wu:fe01f04, anticorps maternal embryonic leucine zipper kinase, anticorps maternal embryonic leucine zipper kinase L homeolog, anticorps MELK, anticorps melk, anticorps cgd5_2270, anticorps Melk, anticorps melk.L

Sujet: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.

Poids moléculaire: 72729

UniProt: Q61846