RAB13 anticorps (AA 1-203)
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- Antigène Voir toutes RAB13 Anticorps
- RAB13 (RAB13, Member RAS Oncogene Family (RAB13))
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Épitope
- AA 1-203
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp RAB13 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein G column, followed by dialysis against PBS.
- Immunogène
- This RAB13 antibody is generated from a mouse immunized with a recombinant protein between 1-203 amino acids from human RAB13.
- Clone
- 1600CT845-37-29
- Isotype
- IgG1
- Top Product
- Discover our top product RAB13 Anticorps primaire
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- Indications d'application
- WB: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Date de péremption
- 6 months
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- Antigène
- RAB13 (RAB13, Member RAS Oncogene Family (RAB13))
- Autre désignation
- RAB13 (RAB13 Produits)
- Synonymes
- anticorps cb764, anticorps hm:zeh0455, anticorps RAB13, anticorps 0610007N03Rik, anticorps B230212B15Rik, anticorps RAB13, member RAS oncogene family, anticorps rab13, anticorps RAB13, anticorps Rab13
- Sujet
- The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
- Poids moléculaire
- 22774
- UniProt
- P51153
- Pathways
- Cell-Cell Junction Organization
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