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RAB13 anticorps (AA 1-203)

RAB13 Reactivité: Humain WB Hôte: Souris Monoclonal 1600CT845-37-29 unconjugated
N° du produit ABIN6242518
  • Antigène Voir toutes RAB13 Anticorps
    RAB13 (RAB13, Member RAS Oncogene Family (RAB13))
    Épitope
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-203
    Reactivité
    • 20
    • 14
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 16
    • 4
    Souris
    Clonalité
    • 16
    • 4
    Monoclonal
    Conjugué
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RAB13 est non-conjugé
    Application
    • 12
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogène
    This RAB13 antibody is generated from a mouse immunized with a recombinant protein between 1-203 amino acids from human RAB13.
    Clone
    1600CT845-37-29
    Isotype
    IgG1
    Top Product
    Discover our top product RAB13 Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    RAB13 (RAB13, Member RAS Oncogene Family (RAB13))
    Autre désignation
    RAB13 (RAB13 Produits)
    Synonymes
    anticorps cb764, anticorps hm:zeh0455, anticorps RAB13, anticorps 0610007N03Rik, anticorps B230212B15Rik, anticorps RAB13, member RAS oncogene family, anticorps rab13, anticorps RAB13, anticorps Rab13
    Sujet
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
    Poids moléculaire
    22774
    UniProt
    P51153
    Pathways
    Cell-Cell Junction Organization
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