PTEN anticorps (AA 363-392)

N° du produit ABIN6242542

Détail du produit anti-PTEN anticorps

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Épitope: AA 363-392

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTEN est non-conjugé

Application: Western Blotting (WB)

Homologie: M, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PTEN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 363-392 amino acids from the Central region of human PTEN.

Clone: RB39439

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur PTEN

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Autre désignation: PTEN (PTEN Produits)

Sujet: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Poids moléculaire: 47166

NCBI Accession: NP_000305

UniProt: P60484

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling