RING1 anticorps (C-Term)

N° du produit ABIN6242605

Détail du produit anti-RING1 anticorps

Antigène: RING1 (Ring Finger Protein 1 (RING1))

Épitope: AA 279-313, C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RING1 est non-conjugé

Application: Western Blotting (WB)

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RING1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 279-313 amino acids from the C-terminal region of human RING1.

Clone: RB51604

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur RING1

Antigène: RING1 (Ring Finger Protein 1 (RING1))

Autre désignation: RING1 (RING1 Produits)

Synonymes: anticorps RING1A, anticorps RNF1, anticorps Ring1A, anticorps bap-1, anticorps bap1, anticorps ding, anticorps hipi3, anticorps ring1a, anticorps ring1b, anticorps ring2, anticorps rnf1, anticorps rnf2-a, anticorps ring1, anticorps ring1b-B, anticorps rnf2-b, anticorps ring finger protein 1, anticorps ring finger protein 1 S homeolog, anticorps ring finger protein 1 L homeolog, anticorps RING1, anticorps Ring1, anticorps ring1.S, anticorps ring1.L

Sujet: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Poids moléculaire: 42429

UniProt: Q06587