VAV3 anticorps (C-Term)
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- Antigène Voir toutes VAV3 Anticorps
- VAV3 (Vav 3 Oncogene (VAV3))
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Épitope
- AA 768-802, C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp VAV3 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogène
- This VAV3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 768-802 amino acids from the C-terminal region of human VAV3.
- Clone
- RB53259
- Isotype
- Ig Fraction
- Top Product
- Discover our top product VAV3 Anticorps primaire
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- Indications d'application
- WB: 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Date de péremption
- 6 months
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- Antigène
- VAV3 (Vav 3 Oncogene (VAV3))
- Autre désignation
- VAV3 (VAV3 Produits)
- Sujet
- Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)- mediated adhesion. Does not affect integrin beta-1 (ITGB1)- mediated adhesion (By similarity).
- Poids moléculaire
- 97776
- UniProt
- Q9UKW4
- Pathways
- Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
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