This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This ZFPM1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 954-987 amino acids from the C-terminal region of human ZFPM1.
anticorps FOG, anticorps FOG1, anticorps ZC2HC11A, anticorps ZNF408, anticorps ZNF89A, anticorps Fog1, anticorps Xfog, anticorps fog, anticorps fog-1, anticorps fog1, anticorps FOG-1, anticorps si:dkey-20g6.1, anticorps si:dkey-38l12.1, anticorps ZNF469, anticorps ZFPM1, anticorps zinc finger protein, FOG family member 1, anticorps zinc finger protein, multitype 1, anticorps zinc finger protein, FOG family member 1 L homeolog, anticorps ZFPM1, anticorps Zfpm1, anticorps zfpm1.L, anticorps zfpm1
Sujet
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).