DKK1 anticorps (AA 1-266)

N° du produit ABIN6242718

Détail du produit anti-DKK1 anticorps

Antigène: DKK1 (Dickkopf Homolog 1 (DKK1))

Épitope: AA 1-266

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DKK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DKK1 antibody is generated from a rabbit immunized with a recombinant protein of human DKK1.

Clone: RB52126

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:25. WB: 1:1000. WB: 1:2000. WB: 1:4000. WB: 1:2000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur DKK1

Antigène: DKK1 (Dickkopf Homolog 1 (DKK1))

Autre désignation: DKK1 (DKK1 Produits)

Synonymes: anticorps DKK-1, anticorps SK, anticorps AI414495, anticorps SGY, anticorps SGY-1, anticorps SGY1, anticorps Soggy, anticorps mSgy, anticorps dkk1, anticorps dkk, anticorps dkk-1, anticorps xdkk1, anticorps Xdkk-1, anticorps Dickkopf1, anticorps dickkopf-1, anticorps mdkk-1, anticorps dkk1-A, anticorps dickkopf WNT signaling pathway inhibitor 1, anticorps dickkopf like acrosomal protein 1, anticorps dickkopf-related protein 1, anticorps dickkopf-like 1, anticorps dickkopf WNT signaling pathway inhibitor 1b, anticorps dickkopf protein, anticorps dickkopf WNT signaling pathway inhibitor 1 S homeolog, anticorps DKK1, anticorps Dkk1, anticorps DKKL1, anticorps LOC100228789, anticorps Dkkl1, anticorps dkk1b, anticorps dkk1, anticorps dickkopf, anticorps dkk1.S

Sujet: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Poids moléculaire: 28672

UniProt: O94907

Pathways: Signalisation WNT, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation