PCGF1 anticorps (AA 117-151)

N° du produit ABIN6242736

Détail du produit anti-PCGF1 anticorps

Antigène: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Épitope: AA 117-151

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCGF1 est non-conjugé

Application: Western Blotting (WB)

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PCGF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 117-151 amino acids from the Central region of human PCGF1.

Clone: RB51308

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur PCGF1

Antigène: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Autre désignation: PCGF1 (PCGF1 Produits)

Synonymes: anticorps PCGF1, anticorps 2010002K04Rik, anticorps NSPC1, anticorps RNF3A-2, anticorps RNF68, anticorps AU024121, anticorps Nspc1, anticorps nspc1, anticorps si:zc207o21.2, anticorps polycomb group ring finger 1, anticorps polycomb group ring finger 1 L homeolog, anticorps PCGF1, anticorps pcgf1, anticorps Pcgf1, anticorps pcgf1.L

Sujet: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6, this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Poids moléculaire: 30346

UniProt: Q9BSM1