JARID2 anticorps (AA 435-468)

N° du produit ABIN6242858

Détail du produit anti-JARID2 anticorps

Antigène: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Épitope: AA 435-468

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JARID2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Jarid2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the Central region of Mouse Jarid2.

Clone: RB52498

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur JARID2

Antigène: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Autre désignation: Jarid2 (JARID2 Produits)

Synonymes: anticorps JMJ, anticorps Jmj, anticorps jumonji, anticorps JARID2, anticorps jarid2, anticorps jmj, anticorps si:dkey-211c3.1, anticorps Jumonji, anticorps jarid2-a, anticorps jarid2-b, anticorps jarid2.S, anticorps jarid2b, anticorps jumonji and AT-rich interaction domain containing 2, anticorps jumonji, AT rich interactive domain 2, anticorps jumonji, AT rich interactive domain 2a, anticorps jumonji, AT rich interactive domain 2b, anticorps jumonji and AT-rich interaction domain containing 2 L homeolog, anticorps JARID2, anticorps Jarid2, anticorps jarid2a, anticorps jarid2, anticorps jarid2b, anticorps jarid2.L

Sujet: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

Poids moléculaire: 137445

UniProt: Q62315

Pathways: Chromatin Binding