PSME4 anticorps (AA 503-535)

N° du produit ABIN6242866

Détail du produit anti-PSME4 anticorps

Antigène: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Épitope: AA 503-535

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSME4 est non-conjugé

Application: Western Blotting (WB)

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PSME4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 503-535 amino acids from human PSME4.

Clone: RB55279

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur PSME4

Antigène: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Autre désignation: PSME4 (PSME4 Produits)

Synonymes: anticorps proteasome activating protein 200, anticorps Afu4g11290, anticorps An04g05320, anticorps AO090003001091, anticorps PA200, anticorps AA409398, anticorps AU041366, anticorps TEMO, anticorps mKIAA0077, anticorps proteasome activator subunit 4, anticorps proteasome activating protein 200, anticorps proteasome (prosome, macropain) activator subunit 4, anticorps PSME4, anticorps Psme4, anticorps PA200, anticorps AFUA_4G11290, anticorps ANI_1_888184, anticorps AOR_1_1944154, anticorps TERG_07227, anticorps psme4

Sujet: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Poids moléculaire: 211334

UniProt: Q14997

Pathways: DNA Replication, Synthesis of DNA