This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This ZFYVE20 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 41-65 amino acids from the human region of human ZFYVE20.
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:< a href="http://www.uniprot.org/citations/11062261" target="_blank">11062261, PubMed:< a href="http://www.uniprot.org/citations/11788822" target="_blank">11788822, PubMed:< a href="http://www.uniprot.org/citations/15020713" target="_blank">15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:< a href="http://www.uniprot.org/citations/22308388" target="_blank">22308388).