Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

SREBF chaperone anticorps (N-Term)

SCAP Reactivité: Humain WB Hôte: Souris Monoclonal 1992C245-37-16 unconjugated
N° du produit ABIN6243003
  • Antigène Voir toutes SREBF chaperone (SCAP) Anticorps
    SREBF chaperone (SCAP)
    Épitope
    • 15
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 49-83, N-Term
    Reactivité
    • 27
    • 18
    • 17
    • 1
    Humain
    Hôte
    • 41
    • 1
    Souris
    Clonalité
    • 41
    • 1
    Monoclonal
    Conjugué
    • 16
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SREBF chaperone est non-conjugé
    Application
    • 33
    • 13
    • 13
    • 12
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogène
    This SCAP antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 49-83 amino acids from the N-terminal region of human SCAP.
    Clone
    1992C245-37-16
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product SCAP Anticorps primaire
  • Indications d'application
    WB: 1:4000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    SREBF chaperone (SCAP)
    Autre désignation
    SCAP (SCAP Produits)
    Synonymes
    anticorps 9530044G19, anticorps mKIAA0199, anticorps SREBF chaperone, anticorps SREBF chaperone S homeolog, anticorps SCAP, anticorps Scap, anticorps scap.S
    Sujet
    Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
    Poids moléculaire
    139729
    UniProt
    Q12770
    Pathways
    SARS-CoV-2 Protein Interactome
Vous êtes ici:
Support technique