SREBF chaperone anticorps (N-Term)

N° du produit ABIN6243003

Détail du produit anti-SREBF chaperone anticorps

Antigène: SREBF chaperone (SCAP)

Épitope: AA 49-83, N-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SREBF chaperone est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This SCAP antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 49-83 amino acids from the N-terminal region of human SCAP.

Clone: 1992C245-37-16

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:4000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur SREBF chaperone

Antigène: SREBF chaperone (SCAP)

Autre désignation: SCAP (SCAP Produits)

Synonymes: anticorps 9530044G19, anticorps mKIAA0199, anticorps SREBF chaperone, anticorps SREBF chaperone S homeolog, anticorps SCAP, anticorps Scap, anticorps scap.S

Sujet: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).

Poids moléculaire: 139729

UniProt: Q12770

Pathways: SARS-CoV-2 Protein Interactome