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DNMT3A anticorps (AA 463-497)

DNMT3A Reactivité: Humain WB Hôte: Lapin Polyclonal RB51574 unconjugated
N° du produit ABIN6243165
  • Antigène Voir toutes DNMT3A Anticorps
    DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
    Épitope
    • 16
    • 16
    • 13
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 463-497
    Reactivité
    • 133
    • 55
    • 53
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 125
    • 10
    Lapin
    Clonalité
    • 118
    • 17
    Polyclonal
    Conjugué
    • 50
    • 11
    • 10
    • 10
    • 8
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp DNMT3A est non-conjugé
    Application
    • 93
    • 59
    • 30
    • 27
    • 26
    • 15
    • 10
    • 9
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    C, M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This DNMT3A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 463-497 amino acids from the Central region of human DNMT3A.
    Clone
    RB51574
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DNMT3A Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
    Autre désignation
    DNMT3A (DNMT3A Produits)
    Synonymes
    anticorps DNMT3A, anticorps DNMT3A2, anticorps M.HsaIIIA, anticorps MmuIIIA, anticorps dnmt3a1, anticorps dnmt6, anticorps DNA methyltransferase 3 alpha, anticorps DNA methyltransferase 3A, anticorps DNA (cytosine-5-)-methyltransferase 3 alpha b, anticorps DNMT3A, anticorps Dnmt3a, anticorps dnmt3a, anticorps dnmt3ab
    Sujet
    Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
    Poids moléculaire
    101858
    UniProt
    Q9Y6K1
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