POLA1 anticorps (AA 1-33)

N° du produit ABIN6243170

Détail du produit anti-POLA1 anticorps

Antigène: POLA1 (DNA Polymerase alpha (POLA1))

Épitope: AA 1-33

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLA1 est non-conjugé

Application: Western Blotting (WB)

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This POLA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-33 amino acids from the human region of human POLA1.

Clone: RB57636

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur POLA1

Antigène: POLA1 (DNA Polymerase alpha (POLA1))

Autre désignation: POLA1 (POLA1 Produits)

Synonymes: anticorps pola, anticorps AW321876, anticorps Pola, anticorps POLA, anticorps p180, anticorps polymerase (DNA directed), alpha 1, catalytic subunit S homeolog, anticorps polymerase (DNA directed), alpha 1, anticorps DNA polymerase alpha 1, catalytic subunit, anticorps pola1.S, anticorps Pola1, anticorps POLA1

Sujet: Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes.

Poids moléculaire: 165913

UniProt: P09884

Pathways: SARS-CoV-2 Protein Interactome