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FGFR1 anticorps (AA 291-324)

FGFR1 Reactivité: Humain, Souris WB, FACS Hôte: Lapin Polyclonal RB50848 unconjugated
N° du produit ABIN6243223
  • Antigène Voir toutes FGFR1 Anticorps
    FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
    Épitope
    • 29
    • 27
    • 19
    • 17
    • 17
    • 16
    • 13
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 291-324
    Reactivité
    • 225
    • 98
    • 95
    • 24
    • 22
    • 15
    • 9
    • 6
    • 6
    • 3
    • 2
    • 2
    Humain, Souris
    Hôte
    • 217
    • 40
    • 1
    Lapin
    Clonalité
    • 210
    • 48
    Polyclonal
    Conjugué
    • 121
    • 21
    • 18
    • 15
    • 11
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FGFR1 est non-conjugé
    Application
    • 223
    • 108
    • 63
    • 57
    • 52
    • 33
    • 25
    • 22
    • 20
    • 15
    • 14
    • 9
    • 7
    • 5
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Homologie
    C, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This FGFR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 291-324 amino acids from the Central region of human FGFR1.
    Clone
    RB50848
    Isotype
    Ig Fraction
    Top Product
    Discover our top product FGFR1 Anticorps primaire
  • Indications d'application
    WB: 1:1000. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Sahni, Patel, Narra, Schroeder, Walker, Sahni: "Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium." dans: PLoS ONE, Vol. 12, Issue 8, pp. e0183181, (2017) (PubMed).

  • Antigène
    FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
    Autre désignation
    FGFR1 (FGFR1 Produits)
    Sujet
    Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
    Poids moléculaire
    91868
    UniProt
    P11362
    Pathways
    Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins
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