LRRK2 anticorps (C-Term)

N° du produit ABIN6243251

Détail du produit anti-LRRK2 anticorps

Antigène: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Épitope: AA 2171-2207, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRRK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This LRRK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2171-2207 amino acids from the C-terminal region of human LRRK2.

Clone: RB50924

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC: 1:25. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur LRRK2

Antigène: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Autre désignation: LRRK2 (LRRK2 Produits)

Synonymes: anticorps LRRK2, anticorps AURA17, anticorps DARDARIN, anticorps PARK8, anticorps RIPK7, anticorps ROCO2, anticorps 4921513O20Rik, anticorps 9330188B09Rik, anticorps AW561911, anticorps D630001M17Rik, anticorps Gm927, anticorps cI-46, anticorps leucine-rich repeat kinase 2, anticorps leucine rich repeat kinase 2, anticorps lrrk2, anticorps LRRK2, anticorps Lrrk2

Sujet: Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH , and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (,CNS),. Phosphorylates PRDX3. May also have GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

Poids moléculaire: 286103

UniProt: Q5S007

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development