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MAP2K7 anticorps (AA 325-360)

MAP2K7 Reactivité: Rat WB Hôte: Lapin Polyclonal RB53023 unconjugated
N° du produit ABIN6243257
  • Antigène Voir toutes MAP2K7 Anticorps
    MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))
    Épitope
    • 31
    • 18
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 325-360
    Reactivité
    • 70
    • 55
    • 52
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Rat
    Hôte
    • 80
    • 5
    Lapin
    Clonalité
    • 73
    • 12
    Polyclonal
    Conjugué
    • 40
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MAP2K7 est non-conjugé
    Application
    • 73
    • 30
    • 27
    • 26
    • 16
    • 16
    • 10
    • 9
    • 6
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This MAP2K7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 325-360 amino acids of human MAP2K7.
    Clone
    RB53023
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MAP2K7 Anticorps primaire
  • Indications d'application
    WB: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))
    Autre désignation
    MAP2K7 (MAP2K7 Produits)
    Sujet
    Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
    Poids moléculaire
    47485
    UniProt
    O14733
    Pathways
    Signalisation MAPK, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling
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