This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This PIP4K2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 329-363 amino acids from the C-terminal region of human PIP4K2A.
anticorps PI5P4KA, anticorps PIP5K2A, anticorps PIP5KII-alpha, anticorps PIP5KIIA, anticorps PIPK, anticorps AW742916, anticorps Pip5k2a, anticorps pipk, anticorps pi5p4ka, anticorps pip5k2a, anticorps pip5kiia, anticorps pip4k2a, anticorps zgc:194746, anticorps zgc:194777, anticorps phosphatidylinositol-5-phosphate 4-kinase type 2 alpha, anticorps phosphatidylinositol-5-phosphate 4-kinase, type II, alpha, anticorps phosphatidylinositol-5-phosphate 4-kinase, type II, alpha S homeolog, anticorps phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a, anticorps PIP4K2A, anticorps Pip4k2a, anticorps pip4k2a.S, anticorps pip4k2a, anticorps pip4k2aa
Sujet
Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.