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GSK3 alpha anticorps (AA 348-382)

GSK3a Reactivité: Souris, Rat WB Hôte: Lapin Polyclonal RB30809 unconjugated
N° du produit ABIN6243413
  • Antigène Voir toutes GSK3 alpha (GSK3a) Anticorps
    GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
    Épitope
    • 31
    • 15
    • 14
    • 12
    • 10
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 348-382
    Reactivité
    • 96
    • 80
    • 63
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    Souris, Rat
    Hôte
    • 109
    • 20
    • 2
    Lapin
    Clonalité
    • 109
    • 24
    Polyclonal
    Conjugué
    • 74
    • 10
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GSK3 alpha est non-conjugé
    Application
    • 104
    • 61
    • 56
    • 18
    • 18
    • 14
    • 13
    • 13
    • 7
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB)
    Homologie
    H, X
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This GSK3A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 348-382 amino acids from the Central region of human GSK3A.
    Clone
    RB30809
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GSK3a Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Fang, Wang, Miao, Kuang, Ma, Wang, Zhang, Xia: "Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis." dans: Biology of reproduction, Vol. 95, Issue 3, pp. 67, (2016) (PubMed).

  • Antigène
    GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
    Autre désignation
    GSK3A (GSK3a Produits)
    Synonymes
    anticorps 2700086H06Rik, anticorps GSK3A, anticorps GSK-3[a], anticorps GSK-3[b], anticorps GSK3, anticorps gsk3a, anticorps xgsk3, anticorps glycogen synthase kinase 3 alpha, anticorps glycogen synthase kinase 3 alpha b, anticorps glycogen synthase kinase 3 alpha S homeolog, anticorps GSK3A, anticorps Gsk3a, anticorps gsk3a, anticorps gsk3ab, anticorps gsk3a.S, anticorps Bm1_31380
    Sujet
    Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
    Poids moléculaire
    50981
    UniProt
    P49840
    Pathways
    Signalisation PI3K-Akt, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, L'effet Warburg
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