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GSK3 beta anticorps (AA 2-33)

GSK3b Reactivité: Humain, Rat WB Hôte: Lapin Polyclonal RB56641 unconjugated
N° du produit ABIN6243415
  • Antigène Voir toutes GSK3 beta (GSK3b) Anticorps
    GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))
    Épitope
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 2-33
    Reactivité
    • 6
    • 5
    • 3
    Humain, Rat
    Hôte
    • 7
    • 2
    Lapin
    Clonalité
    • 7
    • 2
    Polyclonal
    Conjugué
    • 9
    Cet anticorp GSK3 beta est non-conjugé
    Application
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    M, X
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This GSK3B (Ser9) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2-33 amino acids from human GSK3B.
    Clone
    RB56641
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GSK3b Anticorps primaire
  • Indications d'application
    WB: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))
    Autre désignation
    GSK-3B (GSK3b Produits)
    Synonymes
    anticorps GSK3, anticorps GSK-3, anticorps C86142, anticorps GSK-3beta, anticorps 7330414F15Rik, anticorps 8430431H08Rik, anticorps GSK3beta, anticorps fk80d11, anticorps GSK-3[b], anticorps wu:fb68h05, anticorps wu:fk80d11, anticorps gsk-3, anticorps gsk3, anticorps gsk3-beta, anticorps gsk3beta, anticorps xgsk-3, anticorps glycogen synthase kinase 3 beta, anticorps glycogen synthase kinase 3 beta L homeolog, anticorps GSK3B, anticorps Gsk3b, anticorps gsk3b, anticorps gsk3b.L
    Sujet
    Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity.
    Poids moléculaire
    46744
    UniProt
    P49841
    Pathways
    Signalisation WNT, Signalisation Hedgehog, Fc-epsilon Receptor Signaling Pathway, Cellular Glucan Metabolic Process, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Autophagy, BCR Signaling, L'effet Warburg
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