GSK3 beta anticorps (N-Term)

N° du produit ABIN6243417

Il existe 1 publication pour ce produit. L’anticorps anti-GSK3 beta Polyclonal Lapin est utilisé pour la détection de GSK3 beta dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour GSK3 beta anticorps (N-Term) (ABIN6243417)

Antigène: GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSK3 beta est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB03816

Détail du produit anti-GSK3 beta anticorps

Épitope: AA 4-34, N-Term

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This GSK3 beta (GSK3B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-34 amino acids from the N-terminal region of human GSK3 beta (GSK3B).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-GSK3 beta (ABIN6243417)

Li, Jia, Ren, Liu, Gong, Wang, Zhang, Zhao: "Axl mediates tumor invasion and chemosensitivity through PI3K/Akt signaling pathway and is transcriptionally regulated by slug in breast carcinoma." dans: IUBMB life, Vol. 66, Issue 7, pp. 507-18, (2014) (PubMed).

Détails sur GSK3 beta

Antigène: GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))

Autre désignation: GSK3 beta (GSK3B)

Sujet: GSK3B, a member of the Ser/Thr protein kinase family, participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. GSK3B phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. The protein is inhibited when phosphorylated by AKT1 or ILK1. Expressed is detected in testis, thymus, prostate and ovary, and weakly in lung, brain and kidney.

Poids moléculaire: 46744

NCBI Accession: NP_001139628, NP_002084

UniProt: P49841

Pathways: Signalisation WNT, Signalisation Hedgehog, Fc-epsilon Receptor Signaling Pathway, Cellular Glucan Metabolic Process, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Autophagy, BCR Signaling, L'effet Warburg