PIK3R2 anticorps (AA 430-470)

N° du produit ABIN6243583

Détail du produit anti-PIK3R2 anticorps

Antigène: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Épitope: AA 430-470

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIK3R2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 430-470 amino acids from human.

Clone: RB48985

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur PIK3R2

Antigène: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Autre désignation: PIK3R2 (PI3K p85b Produits)

Synonymes: anticorps MPPH, anticorps P85B, anticorps p85, anticorps p85-BETA, anticorps pik3r2, anticorps MGC80449, anticorps p85beta, anticorps phosphoinositide-3-kinase regulatory subunit 2, anticorps phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta), anticorps phosphoinositide-3-kinase, regulatory subunit 2 (beta), anticorps PIK3R2, anticorps pik3r2, anticorps Pik3r2

Sujet: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:< a href="http://www.uniprot.org/citations/23604317" target="_blank">23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Poids moléculaire: 81545

UniProt: O00459

Pathways: VEGF Signaling, BCR Signaling