Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

COMMD1 anticorps

COMMD1 Reactivité: Humain WB Hôte: Lapin Polyclonal RB54338 unconjugated
N° du produit ABIN6243631
  • Antigène Voir toutes COMMD1 Anticorps
    COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))
    Reactivité
    • 41
    • 22
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 45
    • 11
    Lapin
    Clonalité
    • 48
    • 8
    Polyclonal
    Conjugué
    • 26
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp COMMD1 est non-conjugé
    Application
    • 36
    • 21
    • 13
    • 13
    • 10
    • 8
    • 7
    • 5
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This COMMD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4--33 amino acids from human COMMD1.
    Clone
    RB54338
    Isotype
    Ig Fraction
    Top Product
    Discover our top product COMMD1 Anticorps primaire
  • Indications d'application
    WB: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))
    Autre désignation
    COMMD1 (COMMD1 Produits)
    Synonymes
    anticorps C2orf5, anticorps MURR1, anticorps murr1, anticorps commd1, anticorps si:ch211-213b8.2, anticorps DDBDRAFT_0184206, anticorps DDBDRAFT_0266452, anticorps DDB_0184206, anticorps DDB_0266452, anticorps COMMD1, anticorps MGC114682, anticorps AI256843, anticorps Murr1, anticorps U2/Mu, anticorps copper metabolism domain containing 1, anticorps copper metabolism (Murr1) domain containing 1, anticorps COMM domain-containing protein 1, anticorps copper metabolism domain containing 1 L homeolog, anticorps COMM domain containing 1, anticorps COMMD1, anticorps commd1, anticorps comd1, anticorps Commd1, anticorps commd1.L
    Sujet
    Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, in vitro promotes CRL E3 activiy and dissocoiates CAND1 from CUL1 and CUL2 (PubMed:< a href="http://www.uniprot.org/citations/21778237" target="_blank">21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:< a href="http://www.uniprot.org/citations/15799966" target="_blank">15799966, PubMed:< a href="http://www.uniprot.org/citations/17183367" target="_blank">17183367, PubMed:< a href="http://www.uniprot.org/citations/20048074" target="_blank">20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:< a href="http://www.uniprot.org/citations/23515529" target="_blank">23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:< a href="http://www.uniprot.org/citations/14645214" target="_blank">14645214, PubMed:< a href="http://www.uniprot.org/citations/20237237" target="_blank">20237237, PubMed:< a href="http://www.uniprot.org/citations/21741370" target="_blank">21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:< a href="http://www.uniprot.org/citations/21483833" target="_blank">21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:< a href="http://www.uniprot.org/citations/20595380" target="_blank">20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:< a href="http://www.uniprot.org/citations/25355947" target="_blank">25355947). Can bind one copper ion per monomer (PubMed:< a href="http://www.uniprot.org/citations/17309234" target="_blank">17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) (PubMed:< a href="http://www.uniprot.org/citations/18940794" target="_blank">18940794). Involved in the regulation of HIF1A-mediated transcription, competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:< a href="http://www.uniprot.org/citations/20458141" target="_blank">20458141).
    Poids moléculaire
    21178
    UniProt
    Q8N668
    Pathways
    Transition Metal Ion Homeostasis
Vous êtes ici:
Support technique