L3MBTL1 anticorps (AA 451-485)

N° du produit ABIN6243755

Détail du produit anti-L3MBTL1 anticorps

Antigène: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Épitope: AA 451-485

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp L3MBTL1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This L3MBTL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 451-485 amino acids from the Central region of human L3MBTL1.

Clone: RB53645

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur L3MBTL1

Antigène: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Autre désignation: L3MBTL1 (L3MBTL1 Produits)

Synonymes: anticorps C630004G01, anticorps L3mbtl, anticorps mKIAA0681, anticorps H-L(3)MBT, anticorps L3MBTL, anticorps ZC2HC3, anticorps dJ138B7.3, anticorps RGD1307316, anticorps l(3)mbt-like (Drosophila), anticorps L3MBTL1, histone methyl-lysine binding protein, anticorps l(3)mbt-like 1 (Drosophila), anticorps L3mbtl1, anticorps L3MBTL1

Sujet: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.

Poids moléculaire: 92297

UniProt: Q9Y468

Pathways: Chromatin Binding