KISS1 anticorps (AA 115-145)

N° du produit ABIN6243763

Détail du produit anti-KISS1 anticorps

Antigène: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Épitope: AA 115-145

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KISS1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This KISS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 115-145 amino acids from the human region of human KISS1.

Clone: RB53799

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:25. WB: 1:2000. WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur KISS1

Antigène: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Autre désignation: KISS1 (KISS1 Produits)

Synonymes: anticorps HH13, anticorps KiSS-1, anticorps metastatin, anticorps Eseptin, anticorps KiSS-1 metastasis-suppressor, anticorps KISS1, anticorps kiss1, anticorps Kiss1

Sujet: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

Poids moléculaire: 14705

UniProt: Q15726

Pathways: Positive Regulation of Peptide Hormone Secretion