EPH Receptor B3 anticorps (AA 350-382)

N° du produit ABIN6243857

Détail du produit anti-EPH Receptor B3 anticorps

Antigène: EPH Receptor B3 (EPHB3)

Épitope: AA 350-382

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor B3 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Ephb3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 350-382 amino acids from the Central region of Mouse Ephb3.

Clone: RB50405

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur EPH Receptor B3

Antigène: EPH Receptor B3 (EPHB3)

Autre désignation: Ephb3 (EPHB3 Produits)

Synonymes: anticorps tck, anticorps MGC83457, anticorps EPHB3, anticorps ETK2, anticorps HEK2, anticorps TYRO6, anticorps AW456895, anticorps Cek10, anticorps Etk2, anticorps MDK5, anticorps Sek4, anticorps Tyro6, anticorps CEK10, anticorps EK10, anticorps ek3, anticorps ephb3, anticorps fc62d03, anticorps rtk3, anticorps wu:fc62d03, anticorps zek3, anticorps EPH receptor B3, anticorps EPH receptor B3 L homeolog, anticorps Eph receptor B3, anticorps eph receptor B3a, anticorps Eph receptor tyrosine kinase, anticorps EPHB3, anticorps ephb3.L, anticorps ephb3, anticorps Ephb3, anticorps ephb3a

Sujet: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.

Poids moléculaire: 109662

UniProt: P54754

Pathways: Signalisation RTK