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ITK anticorps (AA 228-262)

ITK Reactivité: Humain WB Hôte: Lapin Polyclonal RB50773 unconjugated
N° du produit ABIN6243870
  • Antigène Voir toutes ITK Anticorps
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Épitope
    • 14
    • 10
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 228-262
    Reactivité
    • 49
    • 20
    • 12
    • 6
    • 3
    Humain
    Hôte
    • 61
    • 5
    • 2
    Lapin
    Clonalité
    • 63
    • 5
    Polyclonal
    Conjugué
    • 29
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ITK est non-conjugé
    Application
    • 41
    • 36
    • 14
    • 14
    • 11
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Homologie
    M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This ITK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 228-262 amino acids from the Central region of human ITK.
    Clone
    RB50773
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ITK Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Autre désignation
    ITK (ITK Produits)
    Synonymes
    anticorps Emt, anticorps Tcsk, anticorps Tsk, anticorps EMT, anticorps LPFS1, anticorps LYK, anticorps PSCTK2, anticorps IL2 inducible T cell kinase, anticorps IL2 inducible T-cell kinase, anticorps IL2-inducible T-cell kinase, anticorps Itk, anticorps ITK
    Sujet
    Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
    Poids moléculaire
    71831
    UniProt
    Q08881
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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