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WEE1 anticorps (Ser123)

WEE1 Reactivité: Humain WB Hôte: Lapin Polyclonal RB57984 unconjugated
N° du produit ABIN6243968
  • Antigène Voir toutes WEE1 Anticorps
    WEE1 (WEE1 Homolog (S. Pombe) (WEE1))
    Épitope
    • 20
    • 15
    • 12
    • 11
    • 9
    • 8
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 96-130, Ser123
    Reactivité
    • 94
    • 54
    • 42
    • 2
    Humain
    Hôte
    • 104
    • 5
    • 2
    Lapin
    Clonalité
    • 109
    • 2
    Polyclonal
    Conjugué
    • 44
    • 9
    • 8
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp WEE1 est non-conjugé
    Application
    • 83
    • 51
    • 28
    • 28
    • 23
    • 16
    • 8
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This Wee1(S123) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 96-130 amino acids from human Wee1.
    Clone
    RB57984
    Isotype
    Ig Fraction
    Top Product
    Discover our top product WEE1 Anticorps primaire
  • Indications d'application
    WB: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    WEE1 (WEE1 Homolog (S. Pombe) (WEE1))
    Autre désignation
    Wee1 (WEE1 Produits)
    Synonymes
    anticorps WEE1A, anticorps WEE1hu, anticorps ATWEE1, anticorps F22D16.3, anticorps F22D16_3, anticorps WEE1 kinase homolog, anticorps WEE1-KINASE, anticorps WEE1, anticorps Xe-Wee1B, anticorps XeWee1B, anticorps wee1-b, anticorps wee1a, anticorps wee2-a, anticorps xe-wee1a, anticorps xwee1, anticorps wee1, anticorps wee1b, anticorps wee1hu, anticorps xwee2, anticorps GB19689, anticorps Wee1A, anticorps fa20h03, anticorps wu:fa20h03, anticorps zgc:136514, anticorps WEE1 G2 checkpoint kinase, anticorps Wee1 kinase, anticorps WEE1-like kinase, anticorps WEE1 G2 checkpoint kinase S homeolog, anticorps wee1 homolog, anticorps WEE1 homolog 2, anticorps wee1-like protein kinase, anticorps WEE 1 homolog 1 (S. pombe), anticorps M phase inhibitor protein kinase Wee1, anticorps WEE1, anticorps Wee1, anticorps wee1.S, anticorps wee1-a, anticorps wee2, anticorps LOC551677, anticorps wee1
    Sujet
    Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
    Poids moléculaire
    71597
    UniProt
    P30291
    Pathways
    Cycle Cellulaire, Mitotic G1-G1/S Phases, M Phase
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