WEE1 anticorps (Ser123)

N° du produit ABIN6243968

Détail du produit anti-WEE1 anticorps

Antigène: WEE1 (WEE1 Homolog (S. Pombe) (WEE1))

Épitope: AA 96-130, Ser123

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WEE1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Wee1(S123) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 96-130 amino acids from human Wee1.

Clone: RB57984

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur WEE1

Antigène: WEE1 (WEE1 Homolog (S. Pombe) (WEE1))

Autre désignation: Wee1 (WEE1 Produits)

Synonymes: anticorps WEE1A, anticorps WEE1hu, anticorps ATWEE1, anticorps F22D16.3, anticorps F22D16_3, anticorps WEE1 kinase homolog, anticorps WEE1-KINASE, anticorps WEE1, anticorps Xe-Wee1B, anticorps XeWee1B, anticorps wee1-b, anticorps wee1a, anticorps wee2-a, anticorps xe-wee1a, anticorps xwee1, anticorps wee1, anticorps wee1b, anticorps wee1hu, anticorps xwee2, anticorps GB19689, anticorps Wee1A, anticorps fa20h03, anticorps wu:fa20h03, anticorps zgc:136514, anticorps WEE1 G2 checkpoint kinase, anticorps Wee1 kinase, anticorps WEE1-like kinase, anticorps WEE1 G2 checkpoint kinase S homeolog, anticorps wee1 homolog, anticorps WEE1 homolog 2, anticorps wee1-like protein kinase, anticorps WEE 1 homolog 1 (S. pombe), anticorps M phase inhibitor protein kinase Wee1, anticorps WEE1, anticorps Wee1, anticorps wee1.S, anticorps wee1-a, anticorps wee2, anticorps LOC551677, anticorps wee1

Sujet: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

Poids moléculaire: 71597

UniProt: P30291

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, M Phase