SRGAP2 anticorps (C-Term)

N° du produit ABIN6244084

Détail du produit anti-SRGAP2 anticorps

Antigène: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Épitope: AA 997-1030, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRGAP2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SRGAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 997-1030 amino acids from the C-terminal region of human SRGAP2.

Clone: RB53246

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur SRGAP2

Antigène: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Autre désignation: SRGAP2 (SRGAP2 Produits)

Synonymes: anticorps ARHGAP34, anticorps FNBP2, anticorps SRGAP2A, anticorps SRGAP3, anticorps 9930124L22Rik, anticorps AI448945, anticorps FBP2, anticorps Fnbp2, anticorps srGAP3, anticorps AI452337, anticorps Arhgap14, anticorps D130026O08Rik, anticorps Gbi, anticorps MEGAP, anticorps WRP, anticorps mKIAA0411, anticorps RGD1566016, anticorps srGAP2, anticorps srgap2a, anticorps wu:fb47h12, anticorps zgc:136814, anticorps fnbp2, anticorps srgap2, anticorps SLIT-ROBO Rho GTPase activating protein 2, anticorps SLIT-ROBO Rho GTPase activating protein 3, anticorps SLIT-ROBO Rho GTPase activating protein 2 L homeolog, anticorps SRGAP2, anticorps Srgap2, anticorps Srgap3, anticorps srgap2, anticorps srgap2.L

Sujet: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

Poids moléculaire: 120871

UniProt: O75044