This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This Mouse Uhrf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 472-505 amino acids from the Central region of Mouse Uhrf2.
anticorps NIRF, anticorps RNF107, anticorps URF2, anticorps 2310065A22Rik, anticorps AI426270, anticorps AW214556, anticorps D130071B19Rik, anticorps Nirf, anticorps ubiquitin like with PHD and ring finger domains 2, anticorps ubiquitin-like, containing PHD and RING finger domains 2, anticorps ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase L homeolog, anticorps UHRF2, anticorps Uhrf2, anticorps uhrf2.L
Sujet
E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells.