CAMK2B anticorps (AA 1-503)

N° du produit ABIN6244287

Détail du produit anti-CAMK2B anticorps

Antigène: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Épitope: AA 1-503

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CAMK2B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This CAMK2 beta antibody is generated from a mouse immunized with a recombinant protein between 1-503 amino acids from human CAMK2 beta.

Clone: 1050CT14-1-3

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur CAMK2B

Antigène: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Autre désignation: CAMK2 beta (CAMK2B Produits)

Synonymes: anticorps CAM2, anticorps CAMK2, anticorps CAMKB, anticorps Camk2d, anticorps Ck2b, anticorps camk2, anticorps camk2b, anticorps cam2, anticorps camkb, anticorps CAMK2B, anticorps calcium/calmodulin dependent protein kinase II beta, anticorps calcium/calmodulin-dependent protein kinase II, beta, anticorps calcium/calmodulin-dependent protein kinase II beta, anticorps calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog, anticorps calcium/calmodulin dependent protein kinase (CaM kinase) II beta L homeolog, anticorps calcium/calmodulin-dependent protein kinase (CaM kinase) II beta, anticorps CAMK2B, anticorps Camk2b, anticorps camk2a.S, anticorps camk2b.L

Sujet: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Poids moléculaire: 72678

UniProt: Q13554

Pathways: Signalisation WNT, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity