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ATR anticorps (pSer428)

ATR Reactivité: Humain, Souris, Rat ELISA, IHC, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6255330
  • Antigène Voir toutes ATR Anticorps
    ATR (ATR serine/threonine kinase (ATR))
    Épitope
    • 10
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer428
    Reactivité
    • 45
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 39
    • 5
    • 2
    Lapin
    Clonalité
    • 42
    • 4
    Polyclonal
    Conjugué
    • 30
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ATR est non-conjugé
    Application
    • 26
    • 21
    • 19
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    Specificité
    Phospho -ATR(S428) Antibody detects endogenous levels of ATR only when phosphorylated at S428
     Réactivité croisée
    Humain, Souris, Rat (Rattus)
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human phospho -ATR(S428)
    Isotype
    IgG
    Top Product
    Discover our top product ATR Anticorps primaire
  • Indications d'application
    WB 1:1000-3000 IHC 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C.Stable for 12 months from date of receipt
    Date de péremption
    12 months
  • Antigène
    ATR (ATR serine/threonine kinase (ATR))
    Autre désignation
    ATR (ATR Produits)
    Synonymes
    anticorps FCTCS, anticorps FRP1, anticorps MEC1, anticorps SCKL, anticorps SCKL1, anticorps ATR serine/threonine kinase, anticorps ataxia telangiectasia and Rad3 related, anticorps ATR, anticorps Atr
    Sujet

    Description: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

    Gene: ATR

    Poids moléculaire
    300 kDa
    ID gène
    545
    UniProt
    Q13535
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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