ATR anticorps (pSer428)
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- Antigène Voir toutes ATR Anticorps
- ATR (ATR serine/threonine kinase (ATR))
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Épitope
- pSer428
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ATR est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
- Specificité
- Phospho -ATR(S428) Antibody detects endogenous levels of ATR only when phosphorylated at S428
- Réactivité croisée
- Humain, Souris, Rat (Rattus)
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogène
- A synthesized peptide derived from human phospho -ATR(S428)
- Isotype
- IgG
- Top Product
- Discover our top product ATR Anticorps primaire
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- Indications d'application
- WB 1:1000-3000 IHC 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C.Stable for 12 months from date of receipt
- Date de péremption
- 12 months
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- Antigène
- ATR (ATR serine/threonine kinase (ATR))
- Autre désignation
- ATR (ATR Produits)
- Synonymes
- anticorps FCTCS, anticorps FRP1, anticorps MEC1, anticorps SCKL, anticorps SCKL1, anticorps ATR serine/threonine kinase, anticorps ataxia telangiectasia and Rad3 related, anticorps ATR, anticorps Atr
- Sujet
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Description: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
Gene: ATR
- Poids moléculaire
- 300 kDa
- ID gène
- 545
- UniProt
- Q13535
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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