Retinoic Acid Receptor alpha anticorps (pSer77)

N° du produit ABIN6255501

Détail du produit anti-Retinoic Acid Receptor alpha anticorps

Antigène: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Épitope: pSer77

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoic Acid Receptor alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Phospho-Retinoic Acid Receptor alpha (Ser77) Antibody detects endogenous levels of Retinoic Acid Receptor alpha only when phosphorylated at Sersine 77.

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human Retinoic Acid Receptor alpha around the phosphorylation site of Ser77.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Retinoic Acid Receptor alpha

Antigène: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Autre désignation: RARA (RARA Produits)

Synonymes: anticorps NR1B1, anticorps RAR, anticorps Nr1b1, anticorps RARalpha1, anticorps rar-alpha, anticorps etID309833.12, anticorps rara, anticorps rara2a, anticorps zRAR, anticorps zRAR-alpha, anticorps zgc:109797, anticorps nr1b1, anticorps RAR-ALPHA1, anticorps HS-RARa, anticorps fj66e06, anticorps rara2b, anticorps wu:fj66e06, anticorps retinoic acid receptor alpha, anticorps retinoic acid receptor, alpha, anticorps retinoic acid receptor, alpha a, anticorps retinoic acid receptor alpha L homeolog, anticorps retinoic acid receptor, alpha b, anticorps RARA, anticorps Rara, anticorps LOC100136372, anticorps raraa, anticorps rara.L, anticorps rara, anticorps rarab

Sujet:

Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Gene: RARA

Poids moléculaire: 45kDa

ID gène: 5914

UniProt: P10276

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteins