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LIM Domain Kinase 1 anticorps (pThr508)

LIMK1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated

Western blot analysis of extracts from Hela cells,Hela+H2o2 cells and p-peptide Rat brain tissue, using Phospho-LIMK1 (Thr508) Antibody(af3345) at 1/1000 dilution. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human gastric tissue sections by ICC/IF. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human heart tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat gastric tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat liver tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat tumor tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining mouse splenic tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining Mouse spleen tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human lymphoma tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat lung tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining mouse testicular tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human liver tissue cells by ICC/IF. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human renal clear cell carcinoma tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human colon cancer tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human seminoma tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat appendiceal tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining mouse lung tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining mouse pancreatic tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining Human lung cancer tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining Human lung cancer tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat kidney tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat uterine tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human brain tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining mouse gastric tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human lung cancer tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 staining NIH-3T3 by IF/ICC. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human gastric tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat thymus tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human vascular cancer tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat splenic tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human esophageal carcinoma tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat brain tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human liver cancer tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining human duodenum tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat testicular tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/200 staining Mouse spleen tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat heart tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat ovarian tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining rat intestinal tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining mouse kidney tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 at 1/100 staining mouse brain tissue sections by IHC-P. (LIM Domain Kinase 1 anticorps (pThr508))

Western blot analysis of LIMK1 phosphorylation expression in COLO205 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (LIM Domain Kinase 1 anticorps (pThr508))

ABIN6267554 staining NIH-3T3 by IF/ICC. (LIM Domain Kinase 1 anticorps (pThr508))

43 images

N° du produit ABIN6255701

Fiche de données

Antigène Voir toutes LIM Domain Kinase 1 (LIMK1) Anticorps

LIM Domain Kinase 1 (LIMK1)
Épitope
23

15

15

8

7

7

5

5

4

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pThr508
Reactivité
107

78

73

2

2

1

1

1

1

1
Humain, Souris, Rat
Hôte
101

21

3
Lapin
Anticorps secondaires appropriés
Clonalité
105

20
Polyclonal
Conjugué
59

9

8

5

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2
Cet anticorp LIM Domain Kinase 1 est non-conjugé
Application
90

48

26

26

24

19

16

8

7

6

6

2

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité

Phospho-LIMK1 (Thr508) Antibody detects endogenous levels of LIMK1 only when phosphorylated at Threonine 508.

Homologie

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène

A synthesized peptide derived from human LIMK1 around the phosphorylation site of Thr508.

Isotype

IgG
anti-LIM Domain Kinase 1 (LIMK1) antibody
LIMK1 Reactivité: Humain, Souris, Rat, Singe WB, IHC, IF, IHC (p), FACS Hôte: Souris Monoclonal 3H6 unconjugated

anti-LIM Domain Kinase 1 (LIMK1) antibody
LIMK1 Reactivité: Humain, Souris, Rat, Chien, Singe WB, IHC, IF, IHC (p), FACS Hôte: Souris Monoclonal 6B4 unconjugated

anti-LIM Domain Kinase 1 (LIMK1) (AA 451-550) antibody
LIMK1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated

anti-LIM Domain Kinase 1 (LIMK1) (AA 548-647) antibody
LIMK1 Reactivité: Humain WB, ELISA, IHC (p) Hôte: Souris Monoclonal 1B2 unconjugated

anti-LIM Domain Kinase 1 (LIMK1) (AA 548-647) antibody
LIMK1 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 1A8 unconjugated

anti-LIM Domain Kinase 1 (LIMK1) (AA 548-647) antibody
LIMK1 Reactivité: Humain WB, ELISA, IHC (p) Hôte: Souris Monoclonal 2E9 unconjugated

anti-LIM Domain Kinase 1 (LIMK1) (pThr508) antibody
LIMK1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated

anti-LIM Domain Kinase 1 (LIMK1) (pThr508) antibody
LIMK1 Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated

anti-LIM Domain Kinase 1 (LIMK1) (AA 1-647) antibody
LIMK1 Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated

anti-LIM Domain Kinase 1 (LIMK1) (AA 1-30), (N-Term) antibody
LIMK1 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB3078 unconjugated

Indications d'application

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-500, ELISA(peptide) 1:20000-1:40000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

-20 °C

Stockage commentaire

Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption

12 months
Antigène

LIM Domain Kinase 1 (LIMK1)

Autre désignation

LIMK1 (LIMK1 Produits)

Synonymes

anticorps limk1, anticorps xlimk1, anticorps GB16654, anticorps LIMK1, anticorps LIMK, anticorps LIMK-1, anticorps LIM domain kinase 1, anticorps LIM domain kinase 1a, anticorps LIM domain kinase 1 L homeolog, anticorps LIM-domain containing, protein kinase, anticorps LIMK1, anticorps limk1a, anticorps limk1, anticorps CpipJ_CPIJ000717, anticorps LOC413152, anticorps Limk1, anticorps limk1.L

Sujet

Description: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).
Gene: LIMK1

Poids moléculaire

70kDa

ID gène

3984

UniProt

P53667

Pathways

Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events

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