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GATA4 anticorps (pSer105)

GATA4 Reactivité: Humain, Rat, Souris WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6256094
  • Antigène Voir toutes GATA4 Anticorps
    GATA4 (GATA Binding Protein 4 (GATA4))
    Épitope
    • 15
    • 12
    • 11
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer105
    Reactivité
    • 90
    • 65
    • 62
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 80
    • 10
    • 1
    Lapin
    Clonalité
    • 72
    • 19
    Polyclonal
    Conjugué
    • 56
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GATA4 est non-conjugé
    Application
    • 66
    • 30
    • 21
    • 18
    • 13
    • 13
    • 12
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Phospho-GATA4 (Ser105) Antibody detects endogenous levels of GATA4 only when phosphorylated at Serine 105.
    Homologie
    Pig,Bovine,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human GATA4 around the phosphorylation site of Ser105.
    Isotype
    IgG
    Top Product
    Discover our top product GATA4 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    GATA4 (GATA Binding Protein 4 (GATA4))
    Autre désignation
    GATA4 (GATA4 Produits)
    Synonymes
    anticorps gata-4, anticorps xgata4, anticorps xGATA-4, anticorps MGC81427, anticorps GATA4, anticorps GATA-4, anticorps Gata4, anticorps gata4, anticorps ASD2, anticorps VSD1, anticorps Gata-4, anticorps gata, anticorps GATA binding protein 4, anticorps GATA binding protein 4 L homeolog, anticorps glutamyl-tRNA(Gln) amidotransferase subunit A, anticorps gata4 transcription factor, anticorps GATA binding protein 4 S homeolog, anticorps GATA4, anticorps gata4.L, anticorps gata4, anticorps gatA4, anticorps Gata4, anticorps gata4.S
    Sujet

    Description: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).

    Gene: GATA4

    Poids moléculaire
    44kDa
    ID gène
    2626
    UniProt
    P43694
    Pathways
    Peptide Hormone Metabolism, Carbohydrate Homeostasis
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