HNRNPC anticorps (pSer260)

N° du produit ABIN6256225

Détail du produit anti-HNRNPC anticorps

Antigène: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Épitope: pSer260

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNRNPC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Phospho-hnRNP C1/C2 (Ser260) Antibody detects endogenous levels of hnRNP C1/C2 only when phosphorylated at Serine 260.

Homologie: Horse,Rabbit,Dog,Xenopus

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human hnRNP C1/C2 around the phosphorylation site of Ser260.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur HNRNPC

Antigène: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Autre désignation: HNRNPC (HNRNPC Produits)

Synonymes: anticorps C1, anticorps C2, anticorps HNRNP, anticorps HNRPC, anticorps SNRPC, anticorps MGC53243, anticorps HNRNPC, anticorps bZ1G18.4, anticorps fb57h12, anticorps fi16b11, anticorps wu:fb57h12, anticorps wu:fi16b11, anticorps zgc:55701, anticorps AL022939, anticorps D14Wsu171e, anticorps Hnrpc, anticorps Hnrpc1, anticorps Hnrpc2, anticorps hnRNPC1, anticorps hnRNPC2, anticorps hnrnp-C, anticorps hnRNP C, anticorps hnrnp, anticorps hnrpc, anticorps snrpc, anticorps heterogeneous nuclear ribonucleoprotein C (C1/C2), anticorps heterogeneous nuclear ribonucleoprotein C (C1/C2) S homeolog, anticorps heterogeneous nuclear ribonucleoprotein C, anticorps heterogeneous nuclear ribonucleoprotein C (C1/C2) L homeolog, anticorps HNRNPC, anticorps hnrnpc.S, anticorps hnrnpc, anticorps Hnrnpc, anticorps hnrnpc.L

Sujet:

Description: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

Gene: HNRNPC

Poids moléculaire: 41kDa

ID gène: 3183

UniProt: P07910