Merlin anticorps (pSer518)
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- Antigène Voir toutes Merlin (NF2) Anticorps
- Merlin (NF2) (Neurofibromin 2 (NF2))
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Épitope
- pSer518
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Merlin est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- Phospho-NF2 / Merlin (Ser518) Antibody detects endogenous levels of NF2 / Merlin only when phosphorylated at Serine 518.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogène
- A synthesized peptide derived from human NF2 / Merlin around the phosphorylation site of Ser518.
- Isotype
- IgG
- Top Product
- Discover our top product NF2 Anticorps primaire
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anti-Neurofibromin 2 (NF2) (AA 477-576) antibody
NF2 Reactivité: Humain WB, IF, IP Hôte: Lapin Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 30-239) antibodyNF2 Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 30-311) antibodyNF2 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 230-414) antibodyNF2 Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (pSer518) antibodyNF2 Reactivité: Humain WB, ELISA, IF Hôte: Lapin Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 65-95), (N-Term) antibodyNF2 Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal RB19187 unconjugated
anti-Neurofibromin 2 (NF2) (pSer518) antibodyNF2 Reactivité: Humain WB, ELISA, IHC, IP Hôte: Lapin Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 1-507) antibodyNF2 Reactivité: Humain WB, IF Hôte: Souris Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (C-Term) antibodyNF2 Reactivité: Humain, Souris, Rat WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 19-595) antibodyNF2 Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
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- Indications d'application
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- Merlin (NF2) (Neurofibromin 2 (NF2))
- Autre désignation
- NF2 (NF2 Produits)
- Synonymes
- anticorps ACN, anticorps BANF, anticorps SCH, anticorps NF2, anticorps merlin, anticorps zgc:194620, anticorps zgc:194631, anticorps NF2a, anticorps nf2, anticorps neurofibromin 2, anticorps neurofibromin 2a (merlin), anticorps neurofibromin 2b (merlin), anticorps neurofibromin 2 (merlin) S homeolog, anticorps NF2, anticorps Nf2, anticorps nf2a, anticorps nf2b, anticorps nf2.S
- Sujet
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Description: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Gene: NF2
- Poids moléculaire
- 70kDa
- ID gène
- 4771
- UniProt
- P35240
- Pathways
- Cell-Cell Junction Organization
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