HDAC4 anticorps (pSer632)

N° du produit ABIN6256389

Détail du produit anti-HDAC4 anticorps

Antigène: HDAC4 (Histone Deacetylase 4 (HDAC4))

Épitope: pSer632

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Phospho-HDAC4 (Ser632) Antibody detects endogenous levels of HDAC4 only when phosphorylated at Serine 632.

Homologie: Pig,Zebrafish,Bovine,Sheep,Dog,Chicken,Xenopus

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human HDAC4 around the phosphorylation site of Ser632.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur HDAC4

Antigène: HDAC4 (Histone Deacetylase 4 (HDAC4))

Autre désignation: HDAC4 (HDAC4 Produits)

Synonymes: anticorps CG1770, anticorps DHDAC4, anticorps Dmel\\CG1770, anticorps GC1770, anticorps HDAC, anticorps HDAC4a, anticorps dHDAC4, anticorps dmHDA405, anticorps hdac4, anticorps dana_GLEANR_19966, anticorps DanaGF18710, anticorps GF18710, anticorps HDAC4, anticorps AHO3, anticorps BDMR, anticorps HA6116, anticorps HD4, anticorps HDAC-4, anticorps HDAC-A, anticorps HDACA, anticorps 4932408F19Rik, anticorps AI047285, anticorps wu:fa96d08, anticorps wu:fc56f08, anticorps zgc:152701, anticorps histone deacetylase 4, anticorps hypothetical protein, anticorps Histone deacetylase 4, anticorps GF18710 gene product from transcript GF18710-RC, anticorps PTRG_03699, anticorps PGTG_15512, anticorps HDAC4, anticorps Dana\GF18710, anticorps Hdac4, anticorps hdac4

Sujet:

Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).

Gene: HDAC4

Poids moléculaire: 119kDa

ID gène: 9759

UniProt: P56524

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process