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p21 anticorps (pThr145)

CDKN1A Reactivité: Humain, Souris, Rat WB, ELISA, IF, IHC, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6256478
  • Antigène Voir toutes p21 (CDKN1A) Anticorps
    p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
    Épitope
    • 35
    • 30
    • 16
    • 15
    • 15
    • 10
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr145
    Reactivité
    • 240
    • 120
    • 96
    • 36
    • 13
    • 11
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 207
    • 52
    • 1
    Lapin
    Clonalité
    • 201
    • 58
    • 1
    Polyclonal
    Conjugué
    • 104
    • 17
    • 15
    • 15
    • 10
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp p21 est non-conjugé
    Application
    • 158
    • 92
    • 67
    • 66
    • 66
    • 56
    • 51
    • 42
    • 41
    • 33
    • 20
    • 14
    • 12
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Specificité
    Phospho-p21 Cip1 (Thr145) Antibody detects endogenous levels of p21 Cip1 only when phosphorylated at Threonine 145.
    Homologie
    Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human p21 Cip1 around the phosphorylation site of Thr145.
    Isotype
    IgG
    Top Product
    Discover our top product CDKN1A Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
    Autre désignation
    CDKN1A (CDKN1A Produits)
    Sujet

    Description: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).

    Gene: CDKN1A

    Poids moléculaire
    kDa
    ID gène
    1026
    UniProt
    P38936
    Pathways
    Signalisation p53, Signalisation PI3K-Akt, Cycle Cellulaire, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy
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