ERK1 anticorps (pThr202, pTyr204)

N° du produit ABIN6256503

Détail du produit anti-ERK1 anticorps

Antigène: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Épitope: pThr202, pTyr204

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Phospho-ERK1/2 (Thr202/Tyr204) Antibody detects endogenous levels of ERK1/2 only when phosphorylated at Threonine 202/Tyrosine 204.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human ERK1/2 around the phosphorylation site of Thr202/Tyr204.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-ERK1 (ABIN6256503)

Deng, Cheng, Wu, Wang, Zhou, Huang: "Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells." dans: Neurochemical research, Vol. 42, Issue 8, pp. 2246-2256, (2018) (PubMed).

Li, Xiong, Xu, Duan, Yang, Zhou, Tu: "miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway." dans: Oncotarget, Vol. 8, Issue 20, pp. 32566-32575, (2018) (PubMed).

Xie, Cao, Yang, Xu, Wei, Wang: "Relaxin Attenuates Contrast-Induced Human Proximal Tubular Epithelial Cell Apoptosis by Activation of the PI3K/Akt Signaling Pathway In Vitro." dans: BioMed research international, Vol. 2017, pp. 2869405, (2018) (PubMed).

Peng, Wu, Deng, Zhou, Song, Yang, Zhang, Xu, Xia, Cai, Liu, Peng: "MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)." dans: Oncotarget, Vol. 8, Issue 41, pp. 70550-70563, (2018) (PubMed).

Li, Zhang, Jin, Zou, Wang, Hao, Fu, Jiao, Zhang, Lin, Matsuzaki, Zhao: "Dysifragilone A inhibits LPS‑induced RAW264.7 macrophage activation by blocking the p38 MAPK signaling pathway." dans: Molecular medicine reports, Vol. 17, Issue 1, pp. 674-682, (2018) (PubMed).

Liu, Sun, Zhu, Xiao, Dong, Li: "LncRNA-TCONS_00034812 in cell proliferation and apoptosis of pulmonary artery smooth muscle cells and its mechanism." dans: Journal of cellular physiology, Vol. 233, Issue 6, pp. 4801-4814, (2018) (PubMed).

Liu, Huang, Jin, Zhou, Chen, Li, Chen, Li, Yao, Li, Lan, Ye, Wang: "MicroRNA-370 inhibits the growth and metastasis of lung cancer by down-regulating epidermal growth factor receptor expression." dans: Oncotarget, Vol. 8, Issue 50, pp. 88139-88151, (2018) (PubMed).

Zhang, Fei, Tao, Li, Shen, Wang, Liu, Xu: "Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF-κB Signaling Pathway." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 3848595, (2018) (PubMed).

Chai, Bai, Li, Chen, Zhang: "Biological functions of lung cancer cells are suppressed in co-culture with mesenchymal stem cells isolated from umbilical cord." dans: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 1076-1080, (2018) (PubMed).

Xin, Cao, Shao, Zhang, Zhang, Wang, Liang, Shao, Qi, Li, Zhang, Yang, Sun, Zhang, Jia, Wang: "Chemokine CXCL3 mediates prostate cancer cells proliferation, migration and gene expression changes in an autocrine/paracrine fashion." dans: International urology and nephrology, Vol. 50, Issue 5, pp. 861-868, (2018) (PubMed).

Wu, Wang, Fang, Huang, Sun, Xiao, Yan: "MFAP5 promotes tumor progression and bone metastasis by regulating ERK/MMP signaling pathways in breast cancer." dans: Biochemical and biophysical research communications, Vol. 498, Issue 3, pp. 495-501, (2018) (PubMed).

Tang, Bai, Zou, Meng, Xia, Cheng, Mu, Zhou, Wang, Qin, Cao, Jiang, Chen: "Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure." dans: Neurotoxicology, Vol. 67, pp. 27-36, (2018) (PubMed).

Huang, Song, Tao, Shao, Zeng, Xu, Qi, Sun: "Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells." dans: PLoS ONE, Vol. 13, Issue 4, pp. e0195610, (2018) (PubMed).

Wang, Li, Chen, Yang: "Umbilical cord‑derived mesenchymal stem cells can inhibit the biological functions of melanoma A375 cells." dans: Oncology reports, Vol. 40, Issue 1, pp. 511-517, (2018) (PubMed).

Lu, Jia, Zu, Zhang, Zhao, Shi: "Inhibition of the cyclophilin A-CD147 interaction attenuates right ventricular injury and dysfunction after acute pulmonary embolism in rats." dans: The Journal of biological chemistry, Vol. 293, Issue 31, pp. 12199-12208, (2018) (PubMed).

Zhang, Luan, Li, Liu, Liu, Wang, Li, Wang, Zou, Liu, Matsuzaki, Zhao: "Anti-inflammatory action of ambuic acid, a natural product isolated from the solid culture of Pestalotiopsis neglecta, through blocking ERK/JNK mitogen-activated protein kinase signaling pathway." dans: Experimental and therapeutic medicine, Vol. 16, Issue 2, pp. 1538-1546, (2018) (PubMed).

Wu, Feng, Yang, Zhan, Xu, Hu, Zhu, Zhou: "Electroacupuncture exerts neuroprotective effects on ischemia/reperfusion injury in JNK knockout mice: the underlying mechanism." dans: Neural regeneration research, Vol. 13, Issue 9, pp. 1594-1601, (2018) (PubMed).

Jin, Han, Yang, Hu, Liu, Zhao: "11-O-acetylcyathatriol inhibits MAPK/p38-mediated inflammation in LPS-activated RAW 264.7 macrophages and has a protective effect on ethanol-induced gastric injury." dans: Molecular medicine reports, Vol. 14, Issue 1, pp. 874-80, (2017) (PubMed).

Song, Zhou, Peng, Tao, Yang, Xu, Peng, Ren, Xiang, Wei: "GPR120 promotes adipogenesis through intracellular calcium and extracellular signal-regulated kinase 1/2 signal pathway." dans: Molecular and cellular endocrinology, Vol. 434, pp. 1-13, (2017) (PubMed).

Jin, Song, Wang, Zhang, Qiu, Zhao: "Tiliroside, the major component of Agrimonia pilosa Ledeb ethanol extract, inhibits MAPK/JNK/p38-mediated inflammation in lipopolysaccharide-activated RAW 264.7 macrophages." dans: Experimental and therapeutic medicine, Vol. 12, Issue 1, pp. 499-505, (2017) (PubMed).

Détails sur ERK1

Antigène: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Autre désignation: MAPK3,MAPK1 (MAPK3 Produits)

Synonymes: anticorps ERK-1, anticorps ERK1, anticorps ERT2, anticorps HS44KDAP, anticorps HUMKER1A, anticorps P44ERK1, anticorps P44MAPK, anticorps PRKM3, anticorps p44-ERK1, anticorps p44-MAPK, anticorps Erk-1, anticorps Erk1, anticorps Ert2, anticorps Esrk1, anticorps Mnk1, anticorps Mtap2k, anticorps Prkm3, anticorps p44, anticorps p44erk1, anticorps p44mapk, anticorps ERK3, anticorps ERK6, anticorps P38GAMMA, anticorps PRKM12, anticorps SAPK-3, anticorps SAPK3, anticorps fi06b09, anticorps wu:fi06b09, anticorps zERK1, anticorps Tb08.10J17.940, anticorps MAPK1, anticorps MNK1, anticorps AW123708, anticorps Erk6, anticorps P38gamma, anticorps Prkm12, anticorps Sapk3, anticorps ATMAPK3, anticorps ATMPK3, anticorps T6D9.4, anticorps mitogen-activated protein kinase 3, anticorps mitogen-activated protein kinase 3, anticorps mitogen-activated protein kinase 12, anticorps mitogen activated protein kinase 3, anticorps mitogen-activated serine/threonine-protein kinase, anticorps MAPK3, anticorps Mapk3, anticorps MAPK12, anticorps mapk3, anticorps Tc00.1047053509475.10, anticorps Tb927.8.3550, anticorps Mapk12, anticorps CEK1, anticorps MPK3

Sujet:

Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Gene: MAPK3

Poids moléculaire: 42,44kDa

ID gène: 5595, 5594

UniProt: P27361, P28482

Pathways: Signalisation MAPK, Signalisation RTK, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteins