CEBPB anticorps (pThr235)

N° du produit ABIN6256518

Détail du produit anti-CEBPB anticorps

Antigène: CEBPB (CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB))

Épitope: pThr235

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CEBPB est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Phospho-CEBP Beta (Thr235/Thr188) Antibody detects endogenous levels of CEBP Beta only when phosphorylated at Threonine 235.

Homologie: Pig,Bovine,Rabbit,Dog

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human C/EBP- beta around the phosphorylation site of Thr235.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CEBPB

Antigène: CEBPB (CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB))

Autre désignation: CEBPB (CEBPB Produits)

Synonymes: anticorps C/EBPbeta, anticorps c/ebp-beta, anticorps crp2, anticorps il6dbp, anticorps lap, anticorps nf-il6, anticorps tcf5, anticorps xC/EBPbeta, anticorps cebpbb, anticorps cb380, anticorps c/ebpb, anticorps fe11e05, anticorps wu:fe11e05, anticorps CEBPB, anticorps LOC100136165, anticorps C/EBP-beta, anticorps CRP2, anticorps IL6DBP, anticorps LAP, anticorps NF-IL6, anticorps TCF5, anticorps IL-6DBP, anticorps LIP, anticorps NF-M, anticorps Nfil6, anticorps Il6dbp, anticorps CCAAT/enhancer binding protein beta, anticorps CCAAT/enhancer binding protein beta L homeolog, anticorps CCAAT/enhancer binding protein (C/EBP), beta, anticorps CCAAT/enhancer-binding protein beta, anticorps cebpb, anticorps cebpb.L, anticorps CEBPB, anticorps LOC100136165, anticorps Cebpb

Sujet:

Description: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1, represses expression of DSPP during odontoblast differentiation (By similarity).

Gene: CEBPB

Poids moléculaire: 36kDa

ID gène: 1051

UniProt: P17676

Pathways: Interferon-gamma Pathway, Autophagy, Brown Fat Cell Differentiation