Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

FLT1 anticorps (pTyr1213)

FLT1 Reactivité: Humain, Rat, Souris WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6256626
  • Antigène Voir toutes FLT1 Anticorps
    FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
    Épitope
    • 16
    • 12
    • 11
    • 11
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1213
    Reactivité
    • 142
    • 61
    • 61
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 134
    • 33
    • 3
    • 2
    Lapin
    Clonalité
    • 138
    • 34
    Polyclonal
    Conjugué
    • 90
    • 23
    • 11
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FLT1 est non-conjugé
    Application
    • 106
    • 47
    • 46
    • 34
    • 23
    • 21
    • 16
    • 14
    • 13
    • 13
    • 8
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Phospho-VEGFR1 (Tyr1213) Antibody detects endogenous levels of VEGFR1 only when phosphorylated at Tyrosine 1213.
    Homologie
    Pig,Bovine,Horse,Rabbit,Dog
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human VEGFR1 around the phosphorylation site of Tyr1213.
    Isotype
    IgG
    Top Product
    Discover our top product FLT1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
    Autre désignation
    FLT1 (FLT1 Produits)
    Synonymes
    anticorps FLT, anticorps FLT-1, anticorps VEGFR-1, anticorps VEGFR1, anticorps FLT1, anticorps flt1b, anticorps sFlt1, anticorps AI323757, anticorps Flt-1, anticorps fms related tyrosine kinase 1, anticorps FMS-related tyrosine kinase 1, anticorps vascular endothelial growth factor receptor 1, anticorps fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), anticorps FMS-like tyrosine kinase 1, anticorps vascular endothelial growth factor receptor-1, anticorps FLT1, anticorps Flt1, anticorps CpipJ_CPIJ012087, anticorps flt1, anticorps FLT-1
    Sujet

    Description: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain, it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.

    Gene: FLT1

    Poids moléculaire
    kDa
    ID gène
    2321
    UniProt
    P17948
    Pathways
    Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
Vous êtes ici:
Support technique