PI3K p85 alpha/gamma anticorps (pTyr199, pTyr467)
-
- Antigène Tous les produits PI3K p85 alpha/gamma (PI3K p85a/g)
- PI3K p85 alpha/gamma (PI3K p85a/g) (Phosphoinositide 3 Kinase, p85 alpha/gamma (PI3K p85a/g))
-
Épitope
- pTyr199, pTyr467
-
Reactivité
- Humain, Souris, Rat, Singe
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp PI3K p85 alpha/gamma est non-conjugé
-
Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- Phospho-PI3-kinase p85- alpha/ gamma (Tyr467/199) Antibody detects endogenous levels of PI3-kinase p85- alpha/ gamma only when phosphorylated at Tyrosine 467/199
- Réactivité croisée
- Humain, Singe, Souris, Rat (Rattus)
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogène
- A synthesized peptide derived from human PI3-kinase p85- alpha/ gamma around the phosphorylation site of Tyrosine 467/199
- Isotype
- IgG
-
-
- Indications d'application
- WB 1:500-1:2000 IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C.Stable for 12 months from date of receipt
- Date de péremption
- 12 months
-
-
Angelicin inhibits liver cancer growth in vitro and in vivo." dans: Molecular medicine reports, Vol. 16, Issue 4, pp. 5441-5449, (2018) (PubMed).
: "
-
Angelicin inhibits liver cancer growth in vitro and in vivo." dans: Molecular medicine reports, Vol. 16, Issue 4, pp. 5441-5449, (2018) (PubMed).
-
- Antigène
- PI3K p85 alpha/gamma (PI3K p85a/g) (Phosphoinositide 3 Kinase, p85 alpha/gamma (PI3K p85a/g))
- Autre désignation
- PI3-kinase p85 alpha/ gamma (PI3K p85a/g Produits)
- Sujet
-
Description: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Gene: PIK3R1
- Poids moléculaire
- 54,83kDa
- ID gène
- 5295
- UniProt
- P27986, Q92569
-