EPS15 anticorps (pTyr849)

N° du produit ABIN6256811

Détail du produit anti-EPS15 anticorps

Antigène: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Épitope: pTyr849

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPS15 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Phospho-EPS15 (Tyr849) Antibody detects endogenous levels of EPS15 only when phosphorylated at Tyrosine 849.

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human EPS15 around the phosphorylation site of Tyr849.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur EPS15

Antigène: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Autre désignation: EPS15 (EPS15 Produits)

Synonymes: anticorps AF-1P, anticorps AF1P, anticorps MLLT5, anticorps CG16932, anticorps Dmel\\CG16932, anticorps EH1, anticorps EPS-15, anticorps Eps15, anticorps anon-WO0118547.85, anticorps eps-15, anticorps eps15, anticorps i31, anticorps 2410112D09Rik, anticorps RGD1307641, anticorps epidermal growth factor receptor pathway substrate 15, anticorps Epidermal growth factor receptor pathway substrate clone 15, anticorps hypothetical protein, anticorps EPS15, anticorps Eps-15, anticorps eps15, anticorps Eps15, anticorps PGTG_06574

Sujet:

Description: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR), internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Gene: EPS15

Poids moléculaire: 98kDa

ID gène: 2060

UniProt: P42566

Pathways: EGFR Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, EGFR Downregulation