SH2B2 anticorps (N-Term)

N° du produit ABIN6256908

Détail du produit anti-SH2B2 anticorps

Antigène: SH2B2 (SH2B Adaptor Protein 2 (SH2B2))

Épitope: N-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH2B2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: SH2B2 Antibody detects endogenous levels of total SH2B2.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SH2B2, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SH2B2

Antigène: SH2B2 (SH2B Adaptor Protein 2 (SH2B2))

Autre désignation: SH2B2 (SH2B2 Produits)

Synonymes: anticorps APS, anticorps Aps, anticorps SH2B adaptor protein 2, anticorps SH2B2, anticorps Sh2b2

Sujet:

Description: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.

Gene: SH2B2

Poids moléculaire: 67 kDa

ID gène: 10603

UniProt: O14492

Pathways: Carbohydrate Homeostasis, Brown Fat Cell Differentiation